Picture : Pepe Reina took the second place in the Ranking !

All-time ranking for players with most games in European club competitions

Last midweek, Pepe Reina has played for Villarreal in a Europa League match vs Rennes (1-0).
This games was the goalkeeper's 187th in European club tournaments. He overtook his colleague and countryman Iker Casillas (186) and moved into pure second place in the historical ranking.
Ahead is only Cristiano Ronaldo (197 games), whom Pepe Reina has a chance to catch up with this season, provided his club goes far enough in the tournament and he (at the age of 41) plays regularly.
It is worth noting that Reina became the hero of his significant match. He saved the victory for Villarreal by saving a penalty in stoppage time.
The all-time ranking for players with most game in the European club competitions is given below. 
16 players have 150+ games at the moment; 6 of them are active (taken in bold); only 2 of them currently play in Europe (taken in red). 

 PlayerCountryCLCQELCCCOICSCTotalFirst GameLast Game
1Cristiano RonaldoPortugal18348   219714/08/200203/11/2022
2Pepe ReinaSpain761276 715118706/12/200005/10/2023
3Iker CasillasSpain17742   318615/09/199917/04/2019
4Xavi Spain151613   317316/09/199806/06/2015
5Paolo MaldiniItaly1093022   716817/09/198526/02/2009
6Lionel MessiArgentina163     416707/12/200408/03/2023
7Gianluigi BuffonItaly124835    16723/09/199608/12/2020
8Clarence SeedorfNetherlands1256252  316103/11/199203/04/2012
9Javier ZanettiArgentina97854   116011/09/199514/03/2013
10RaúlSpain142211   315812/09/199505/04/2012
11Ryan GiggsWales1411051  115805/11/199101/04/2014
12Karim BenzemaFrance152     515706/12/200517/05/2023
13Dani AlvesBrazil111336   515530/09/200406/03/2019
14Toni KroosGermany14126   515404/10/200703/10/2023
15Zlatan IbrahimovićSweden124421   115008/08/200107/12/2021
16Jamie CarragherEngland801157   215029/09/199721/02/2013

We break down the total goals for each player by tournaments:
Champions League, main stage (CL), 
Champions League, qualification (CQ), 
Fairs’ Cup/ UEFA Cup/Europa League (EL), 
Cup Winners' Cup (CC),
Conference League (CO), 
Intertoto Cup (IC), 
Super Cup (SC).
Tie-breaker: games in Champions League.